inflammation in metabolic syndrome: role of adipose tissue

metabolic syndrome is a chronic low-grade inflammation condition which is associated with central obesity, dyslipidemia, insulin resistance and hypertension. inflammation in metabolic syndrome is not only associated with elevated serum inflammatory markers, such as c-reactive protein (crp), but also, is associated with low-grade inflammation in adipose tissue and releasing of adipokines. higher secretion of adipokines such as adiponectin and leptin, activated macrophages, and signaling pathways such as nuclear factor kappa b (nfkβ) are reported in adipocytes. it seems that more knowledge regarding the role of inflammatory markers in adipose tissue may be useful in management of metabolic syndrome.